Settlement in case of death

If you are in the process of drawing up a separation agreement ( the dependent spouse is not in the marital home); can you state in the separation agreement that should the dependent spouse die before a settlement is reached that their assets (primarily the 50% of home) go to whomever they choose? We are talking about at least $100K.

You can sever the tenancy by the entirety via deed- and create a tenancy in common- then each of your halves would go to your respective heirs.